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High dose intravenous vitamin C could be the most underutilized complementary cancer treatment, but could also be the most studied. In this article we will look at the latest information from IVC clinical trials. Before we end,  I will detail 4 clinical trials that show this treatment can’t be ignored.

Professor of Cancer Cell Biology at Harvard Medical School excited about IVC trial results.

National Cancer Institute invests $10 Million into IVC research.

IVC showing amazing results.

When you lay out the data from the 71 pre-clinical trials, the facts show that a positive result was achieved 92% of the time. IVC was synergistic or enhanced effectiveness of chemo drugs like carboplatin, chlorambucil, 5-FU, gemcitabine, temozolomide as well as synergy with immunotherapy treatments. Additionally high dose IVC has been shown to have radio-sensitizing effect on cancer cells while protecting healthy cells.

Four Clinical examples of using high dose vitamin C to treat cancer.

These positive results have carried over to clinical trials that include patients with a variety of cancer types. I will cover four examples of great results from this promising treatment, but for those that want to read more we also included links to the studies in the description.  

Example 1: IVC improves survival for advanced cancer patients

Furthermore, following treatment with IVC, two patients' tumors shrank enough to become eligible for surgery to remove the tumor. The authors stated that IVC offers “protection from radiation damage in normal surrounding tissue, making it an optimal agent for potentially improving locally advanced pancreatic adenocarcinoma.”. The researchers proceeded to a phase II trial.

Example 2: IVC helps decrease tumor size for 88% of metastatic cancer patients.

Our next example is a phase I trial that included stage IV pancreatic cancer patients receiving IVC, gemcitabine, and erlotinib. After 8 weeks of treatment, 88% of the patients experienced a decrease in primary tumor size. The researchers noted these are incredible results that are superior to “gemcitabine alone or gemcitabine plus erlotinib”.

Example 3: High dose vitamin C improves disease control rate for stage III and IV cancer.

The third example is for an ongoing phase II clinical trial that includes stage IIIB and IV non-small cell lung cancer patients receiving IVC, paclitaxel, and carboplatin. The published evidence shows that IVC massively improves the disease control rate to 93%; historically paclitaxel and carboplatin without IVC delivered only 40% disease control rate.

The authors summarize their findings by stating “we demonstrate that pharmacological ascorbate (vitamin C) represents an easily implementable and non-toxic agent that may increase treatment efficacy when combined with standard-of-care radio-chemotherapy in NSCLC”.

Example 4: High dose intravenous vitamin C reduces toxicity from chemotherapy

IVC, alternative or complementary cancer treatment?

For many years high dose IV vitamin C has been labeled an “alternative” cancer treatment, but studies completed in the last decade are proving IVC can belong in the “standard treatment” toolkit. Major cancer centers like Johns  Hopkins, Mayo Clinic, Sloan Kettering, and Holden Cancer Center are presently conducting studies to make even more progress. 

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