Breast Cancer Vitamin C Treatment | Pre-Clinical Study Results
This article summarizes the evidence provided from pre-clinical studies that investigated how high dose vitamin C improves the capability of chemo, hormonal, and targeted cancer treatments. The research fact table is shown after the evidence summary.
Important Note:
Michela Codini, a pharmaceutical science researcher who authored 21 publications with over 190 citations, makes a compelling case why Vitamin C can “be an excellent complementary remedy to conventional therapies for breast cancer” in her November 2020 article published by NIH.
Pre-Clinical Studies
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The first four studies sought to test the anti-cancer effect of high dose intravenous vitamin C (IVC) in combination with conventional breast cancer treatments. IVC was tested in tandem with eribulin mesylate, tamoxifen, fulvestrant, and trastuzumab. They observed IVC combined with each standard therapy prevented growth of breast cancer cells, but had no negative effect on normal cells. A significant impact was observed on breast cancer cell lines MDA-MB-231, MCF-7, and SK-BR-3.
In all cases the combination treatment with IVC provided a superior anti-tumor effect compared to any of the drugs individually. Evidence also indicates that high-dose vitamin C has an anti-proliferative effects on various anticancer-drug-resistant cell lines, specifically: tamoxifen-resistant (TAM-R) MCF-7, LTED MCF-7, docetaxel-resistant MCF-7 and MDA-MB-231, and doxorubicin-resistant MCF-7 and MDA-MB-231 cells.
5
Another study reviewed the synergistic effect of combining IVC with Topotecan (TPT). Their study showed TPT had greater than 75 times the ability to damage MCF-7 breast cancer cells with the addition of ascorbic acid (Vitamin C). The authors further reported “ascorbic acid significantly enhanced the DNA damage induced by TPT, indicating that the synergistic cytotoxicity of the combination observed in this study is related to this increased DNA damage”.
6
The sixth study documented Triethylenetetramine (TETA) synergizes with high-dose vitamin C to enhance hydrogen peroxide production resulting in apoptosis (tumor cell death). This mechanism of action is similar to what occurred in the other studies.
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The final study in the table shows IVC in combination with immune checkpoint therapy (ICT) can delay cancer growth and “can be curative in models of mismatch repair-deficient tumors with high mutational burden”. They recommended clinical trials take place to further observe the effects of IVC with ICT.
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The information, including but not limited to, text, graphics, images and other material contained on this website are for information purposes only and was based on the latest research accessible to the author at the time of publication. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new healthcare regiment, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Evidence Based Vitamin C Cancer Treatment Medical Articles
Our goal is to analyze the worlds collection of medical studies that are focused on cancer fighting nutrients and health optimizing nutrition, then organize the information so everyone can understand it. By doing this, we hope everyone can make evidence based nutritional decisions that will help them live longer and more rewarding lives.
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Olena has over 10 years of clinical experience including work with Johns Hopkins Hospitals and University of Maryland Medical Center. She supported treating advanced cancer patients with sophisticated therapies that include stem cell transplants and cellular immunotherapy. She also has clinical experience diagnosing and treating patients with a variety of illness and chronic diseases.